I've been impressed with Google Chrome, although the benefits beyond IE8 are marginal. It is a very smart play by Google for reasons that are beyond the scope of this post.
I had a problem on my home media PC (Vista Home Premium) where the Window control buttons (Minimize, Maximize, Close) were not responding to mouse clicks. It was fixed by disabling display scaling: Start > All Programs > Google Chrome > Google Chrome properties (right-click) > Compatibility > "Disable display scaling on high DPI settings".
I run with very large text and see this sort of problem with many applications (including many from Microsoft). Vista has more options for coping with this sort of thing, but some programs are still unusable.
Why did the problem manifest in this way in Chrome? I noticed that the layout of the system bar (at the top of the application) is non-standard when maximized to squeeze in another 20 pixels of content (20 / 1080 = 2% = not worth the trouble IMHO). This implies some hack into the display rendering and event handling code; my guess is that it is not fully DPI aware.
I don't want to take anything away from the Chrome team though: they are clearly excellent Windows application developers. I look forward to browsing the source code.